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Abstract
In the application of antiarrhythmic drugs in patients, a thorough knowledge of their pharmacological effects greatly aids the clinician in the more rational selection of the drug or combination of drugs in terms of expected benefits, favourable additive actions, and contra-indications. Each of the agents depresses disorders of rapid impulse formation (repetitive ectopic pacemaker activity) by reducing diastolic depolarisation and thereby diminishing automaticity, and inhibits disorders of impulse conduction (re-entry tachyarrhythmias) by altering conduction velocity and refractory period and thereby interrupting reciprocal excitation pathways.
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