Abstract
Antiandrogen treatments in gynecology reach from prepuberty to postmenopause. Antiandrogens influence pubertas praecox acne seborrhea alopecia hirsutism/virility menstrual cycle and fertility. A table is included showing the structure and action of antiandrogens. For treatment 2 antiandrogens are considered: cyproterone acetate and chlormadinone acetate. The action of these substances is realized by the following mechanisms: competitive action upon the androgen receptors of sebaceous glands and hair follicles; action upon luteinizing hormone/follicle stimulating hormone secretion (antigonadotrop) effect on the ACTH secretion (anticorticotrop) and effect on enzymes of steroid metabolism. There are various treatments with antiandrogens: solely antiandrogens (with and without interruption) antiandrogens together with estrogens (with interruption) with an estrogen-gestagen combination (with interruption) and together with corticoids (with and without interruption). Side effects of preparations containing cyproterone acetate are similar to those found in oral contraceptives. Therapeutic effect seems to last about 3 months. In most cases the old symptoms reappear after 9 months. Therefore continuing treatment is recommended according to schemes represented in a table.
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