Abstract
Four isomeric methoxy substituted DCK analogues (3–6) were asymmetrically synthesized from different starting materials. 5-Methoxy-3′,4′-di-O-(−)-camphanoyl-(+)-cis-khellactone (5) exhibited extremely potent anti-HIV activity against HIV-1 replication in H9 lymphocyte cells with EC50 and therapeutic index values of 0.00038 μM and >402,632, respectively, which are better than those of DCK and AZT in this assay.
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