Abstract
Two thia-DCK analogs ( 3a, b) were synthesized and evaluated for inhibition of HIV-1 replication in H9 lymphocytes. Compound 3a showed potent anti-HIV activity with an EC 50 value of 0.14 μM and a therapeutic index of 1110. However, the corresponding 6- tert-butyl-substituted compound ( 3b) showed no suppression. The bioassay results indicated that thia-DCK analogs merit attention as potential HIV-1 inhibitors.
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