Anti-Aging Strategies And Topical Delivery Of Biopolymer-Based Nanocarriers For Skin Cancer Treatment.

Abstract

Environmental factors like UV radiation and epigenetic changes are one of the major factors for skin cancer that triggers aging. This review provides basic information on cancer development with respect to aging the receptors involved and the therapeutic targets. Biopolymers like polysaccharide, polyphenols, proteins, nucleic acid plays a vital role in regulation of normal cell homeostasis. It is therefore pertinent to explore the role of biopolymers as antiaging formulations and also the possibility of these formulations used against cancer via topical administrations. As UV radiation is one of the predominant factor in causing skin cancer the association of receptors between aging and cancer indicated that insulin receptor, melatonin receptor, toll like receptor, sirtuin 1 receptor, tumor specific T cell receptor and mitochondria based targeting can be used to direct therapeutics for suppression of cancer and prevent aging. Biopolymer based nanoformulations have tremendously progressed by entrapment of drugs like curcumin, resveratrol which can prevent cancer and aging in a similar mechanism. Certain protein signalling or calcium and ROS signalling pathways are different for cancer and aging process. The involvement of mitochondrial DNA mutation along with telomere shortening with a change in cellular energetics leading to genomic instability in aging process can also induce mitochondrial dysfunction and epigenetic alterations leading to skin cancer. Therefore, the use of biopolymers as a topical supplement during aging process can result in the prevention of cancer.