Abstract
The antiaging effect of Inula britannica flower total flavonoids (IBFTF) on aging mice induced by D-galactose and its mechanism was examined in this study. From the results, the biochemical indexes and histological analysis of skin tissues showed that IBFTF could effectively improve the antioxidant enzyme activity of the aging mice, enhance the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) of skin tissue, and decrease the malondialdehyde (MDA) content. Besides, IBFTF could maintain the skin collagen, hydroxyproline (Hyp), dermal thickness, and moisture content. Meanwhile, IBFTF could significantly reduce the number of cells arrested in G0/G1 phase, and from the point of view of protein and mRNA expression level in skin tissue, IBFTF could significantly increase the expression of Sirt1 and CyclinD1 but decrease the expression of p16 and p21, and its effect was not less than that of the well-known vitamin E (VE). Overall, these results seem to be implying that IBFTF is a potential natural anti-skin aging agent with great antioxidant ability.
Highlights
From the biological viewpoint, aging is an inevitable spontaneous process and complex natural phenomenon [1]
There are many factors that cause aging, including telomere shortening, oncogene activation, and DNA damage caused by reactive oxygen species (ROS), among which the most critical factor is the imbalance of oxygen free radical metabolism [2]
Compared with the model group, the antioxidant activity of Vit E and Inula britannica flower total flavonoids (IBFTF) groups was significantly improved, and MDA was significantly decreased in a dose dependent manner, but there was no significant difference between Vit E and the high dose IBFTF group
Summary
From the biological viewpoint, aging is an inevitable spontaneous process and complex natural phenomenon [1]. The skin changes were most observed, which mainly performs as follows: gloomy skin, relaxation, moisture reduction, thinning, and so on. Free radical theory holds that because of the imbalance of free radical metabolism, the structure and function of tissues and organs are in disorder, which causes the body aging [3]. An aging mouse model induced by D-galactose has been recognized by domestic and international researchers and widely used in the field of antiaging medicine research [5]. The aging degree of the model was close to 16–24 months of mouse, and all these changes were consistent with natural aging [6]
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