Antiaging effect of brown macroalgae Sargassum cristaefolium gel formulation by inhibition of collagen degradation

Abstract

Recent strategies for skin protection against UV radiation have included the incorporation of natural photoprotective agents, such as gel formulations. Our previous study demonstrated the UV photoprotective activity of brown macroalgae Sargassum cristaefolium ethanol extract (SCE). In this study, we aim to determine the optimum gel formulation for the incorporation of SCE. In addition, the UV antiaging activity was evaluated in vivo with mice as animal models. Gel formulation with various concentrations of Glycerin, Carbopol, and TEA was evaluated with the simple lattice design (SLD) method in Design-Expert Software. The optimum gel formula containing 0.1% SCE inhibited collagen degradation in mice skin irradiated by UV-A. It can be concluded that the gel formula successfully incorporates SCE and possibly provides antiaging activity in vivo by inhibition of collagen degradation. However, further investigations need to be done to conclude the photoprotective activity of SCE gel formulation (SCEg). In addition, exploration of the Sargassum brown macroalgae based gel formula should be considered for cosmeceutical applications.