Abstract
Glycosaminoglycans have been used to diminish deleterious effects associated with aging by preventing destruction of cartilage, bone, discs, and skin. The objective of this study was to evaluate the anti‐aging effect of a newly prepared glycosaminoglycan (GAG) derived from bumblebee (Bombus terrestris) queen (BtQG, 10 mg/kg). Gryllus bimaculatus (Gb, cricket) GAG (GbG, 10 mg/kg) or glucosamine sulfate (25 mg/kg) was used as a positive control. They were intraperitoneally administered to old SD rats as part of their diets for one month. BtQG reduced serum levels of creatinine and BUN. It possessed anti‐lipidemic activities, hepato‐and renal‐protective actions, and maintained normal glucose level in treated rats. BtQG and GbG had marked anti‐inflammatory effects. They inhibited free fatty acid, ALP, and sGPT values. In addition, they showed anticoagulant and antithrombotic effects. The concentration of factor 1 (fibrinogen) was increased in BtQG treated rat plasma. In microarray study, CaG5‐treated rat group shows upregulation of 36 genes compared to the control group, including secretogranin II (Scg2), AP‐1‐regulated protein related ROS DNA damage repair, metallothionein 1a, metallothionein 1M, and alpha‐2 macroglobulin. It also showed 417 downregulated genes, including vimentin, moesin, an d mitochondrial carbonic anhydrase.Support or Funding InformationThis work was supported by the Rural Development Administration Basic Research project, PJ011853This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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