Abstract

The effect of Jambolan (Eugenia jambolana) L. spray dried and freeze dried powders (EJP) on modulating stress response signaling was evaluated in transgenic C. elegans carrying promoter‐GFP constructs for several genes in the IGFR/PI3K/AKT, ARE/NRF2 and Sir2.1/AMPK signaling pathways. Relative fold changes in gene expression in response to EJP treatments were quantified flurometrically. Effect of EJP on longevity was evaluated in C. elegans lifespan assays. Anti‐neurodegenerative effects of EJP were evaluated in C. elegans models for Alzheimer’s disease (AD). Where, time to thermally induced Aβ1‐42 aggregation mediated paralysis was evaluated in transgenic C. elegans (CL4176). Results suggest that the processing technology used to produce EJP powders significantly impacted bioactivity. An upregulation in ARE and Sir2.1 stress response genes was noted in response to EJP treatment. A 10‐13% increase in lifespan was observed with EJP treatment. Supplementation with polar acidic, polar basic and polar neutral fractions delayed Aβ1‐42 induced paralysis by 8‐14%.Grant Funding Source: Supported by: Vrdür Foundation (USA) & CAPES (Brazil)

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