Abstract
Newly developed photoreactive azidophenyl chitosan (P‐ALMC) has characteristics of a transformable gel type and its outer layer could be sealed up like a film after UV radiation. We aim to evaluate the antiadhesive properties of P‐ALMC through comparing it with hyaluronic acid‐carboxymethylcellulose membrane (HA‐CMC) in a rabbit laminotomy model. Laminotomies were performed at the L3‐4, L4‐5, and L5‐6 levels in 41 rabbits and each level was randomly assigned to either receive saline (group I), HA‐CMC (group II), or P‐ALMC (group III). The extent of peridural fibrosis, density of fibroblasts and inflammatory cells, and dural thickness were evaluated at 6 and 12 weeks postoperatively. In the groups II and III, the extents of peridural fibrosis and dural thickness were significantly smaller than those in group I (P < 0.001) and no differences between groups II and III were found at the postoperative 6 and 12 weeks. There were no differences of cell density among groups. P‐ALMC showed effective antiadhesive properties comparable to HA‐CMC and could be one of the candidates as an anti‐adhesive agent for spine surgery even further study is required to identify the effectiveness of its unique characteristics as mechanical barrier.
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