Anti-Yo antibody mediated paraneoplastic cerebellar degeneration with breast carcinoma: Rare case report

Abstract

Paraneoplastic cerebellar degeneration is a rare, severely debilitating neurodegenerative syndrome with antibodies targeting Purkinje cells of the cerebellum. It has been associated with fever than 1% of cancers, including small cell carcinoma of the lung, breast cancer, Hodgkin lymphoma and gynaecologic malignancies. Anti-Yo antibody frequently associated with this syndrome and associated with poor prognosis We are reporting a rare case report of anti-Yo antibody mediated cerebellar degeneration in patient with highly aggressive carcinoma of breast.