Abstract
BackgroundThe fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects. Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin.MethodsThe inhibitory effects of honeybush extract and fermented honeybush on wrinkle formation were determined by analyzing skin replicas, histologically examining epidermal thickness, and identifying damage to collagen fibers.ResultsHoneybush extract and fermented honeybush reduced the length and depth of skin winkles caused by UV irradiation and inhibited thickening of the epidermal layer, in addition to suppressing collagen tissue breakdown reactions, indicating its potential use as a skin wrinkle prevention agent.ConclusionsThis in vivo study demonstrates that honeybush produces significant anti-wrinkle effects and is therefore of interest in anti-aging skin care products.
Highlights
The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects
Materials Honeybush was purchased from Renewallife [http://www. renewallife.com, Korea, a voucher specimen (KIOM-HB 2010)] in a herbarium in which the temperature was maintained at 5.5 ± 0.3°C and the humidity was maintained at 50 ± 5%
1 mL of lactic acid bacteria (Streptococcus thermophilus, 3 × 105 CFU/mL) cultured in MRS medium was inoculated in 100 mL of milk with 3 g of sugar and the honeybush extract (5%, w/v), and the mixture was fermented in a 37°C incubator for 1 day
Summary
The fermented leaves and stems of Cyclopia intermedia are used to brew honeybush tea, an herbal tea indigenous to South Africa with reported anti-wrinkle effects. Wrinkle formation caused by photoaging clearly involves changes in extracellular matrix components and mechanical properties of the skin. Methods: The inhibitory effects of honeybush extract and fermented honeybush on wrinkle formation were determined by analyzing skin replicas, histologically examining epidermal thickness, and identifying damage to collagen fibers. Results: Honeybush extract and fermented honeybush reduced the length and depth of skin winkles caused by UV irradiation and inhibited thickening of the epidermal layer, in addition to suppressing collagen tissue breakdown reactions, indicating its potential use as a skin wrinkle prevention agent. Skin photoaging by UVB radiation is clinically and histologically distinct from the natural aging process of the skin, and is characterized by wrinkles, uneven pigmentation, brown spots, laxity, and a leathery appearance [2]. The UVB are mostly responsible for skin changes such as wrinkle formation, epidermal thickening, degradation of matrix macromolecules, vascularization, and immunosuppression. UVA is partly absorbed and has lower efficiency in skin damage like erythema [3,4,5].
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