Abstract
Mass treatment with antifilarial drugs is the mainstay of the Global Programme to Eliminate Lymphatic Filariasis a parasitic disease which is an important cause of chronic morbidity in tropical countries. Current drugs—diethylcarbamazine or ivermectin usually given with albendazole—effectively kill the microfilariae (larval offspring of the parasite) but their effect on the macrofilariae (adult worms) is incomplete. The search for macrofilaricides remains a research priority. One of the most promising leads is treatment directed at Wolbachia the intracellular bacterial symbiont of filarial parasites. In today’s Lancet Mark Taylor and colleagues provide convincing evidence that depletion of Wolbachia by doxycycline kills most adult worms without causing severe side-effects. (excerpt)
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