Abstract
RATIONALE: Atopic dermatitis (AD) patients suffer from recurrent viral skin infections. The increased susceptibility of these patients may be due to deficiencies in the innate immune response. MIP-3α is a C-C chemokine known to have antimicrobial effects, however, it's activity against viral pathogens is unknown. This study investigated the anti-viral activity of MIP-3α against vaccinia virus (VV), the smallpox vaccine, and examined MIP-3α gene expression in the skin of normal subjects, AD patients and psoriasis patients.
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