Anti-Urolithiatic Activity of Filipendula ulmaria Leave Extracts in Male Albino Rats

Abstract

Filipendula ulmaria L. is a perennial herb that can be found in regions with higher humidity in Asia, and Europe. The herb is used medicinally as drugs for several purposes such as facilitating renal elimination functions and many biological activities. The present study is to investigate the anti-Urolithiatic activity of Filipendula ulmaria leaf extracts. The influence of oral administration of aqueous, methanolic and ethanolic extracts of Filipendula ulmaria leaves on calcium oxalate urolithiasis has been investigated. Nephrolithiasis was induced in the rats by adding ethylene glycol (0.75%) in drinking water for 28 day.Animals were divided into nine groups, each containing six viz. Normal control, and ethylene glycol, cystone,Filipendula ulmaria leave extracts in different doses of 100 and 200mg/kg p.o. The aqueous and methanolic extracts showed significant reduction in the urine parameters compared to ethanolic extracts, whereas the cystone showed more reduction compared to the two extracts. Cystone has higher impact on the serum parameters compared to the extracts, whereas the methanolic and ethanolic extracts had higher activity compared to the aqueous extract. Also the methanolic and ethanolic extracts had higher activity compared to the aqueous extract regarding the kidney parameters. The results revealed that the methanolic and ethanol extracts of Filipendula ulmaria leaves have potent antiurolithiatic activity against ethylene glycol-induced calcium oxalate urolithiasis in male albino rats.