Abstract
There are strong beliefs in the efficacy of traditional medical systems worldwide. Many herbs have been acclaimed to possess antiulcer effects and could be unexplored sources of new lead compounds. Sida corymbosa R. E. Fries (Malvaceae) is used in Northern Nigeria to treat ulcers and wounds. This work aimed to investigate the usefulness of Sida corymbosa in treatments of stomach ulcers and wounds in traditional medicine. Effect of the aqueous extract was determined on gastric ulceration, rate of wound healing and inflammation using ethanol-induced and diclofenac-induced ulceration, wound excision model and albumin-induced inflammation respectively in rats. The study demonstrated the anti-ulcer activity of Sida corymbosa as the extract (250, 500 and 1000 mg/kg) showed a dose-dependent, significant (P<0.05) reduction of ulcer indices against gastric ulcers induced by both ethanol and diclofenac. Topical application of a formulation prepared with the extract of Sida corymbosa on surgically created incisions produced an increase in the rate of healing of the wounds. The extract of Sida corymbosa exhibited a significant (P < 0.05), dose-related decrease in inflammation induced by fresh egg albumin. This study showed that Sida corymbosa has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce inflammation. These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents. This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds.
Highlights
There are strong beliefs in the efficacy of traditional medical systems worldwide
Sida corymbosa extract at doses of 250, 500 and 1000 mg/kg showed a dose-dependent, significant (P
The present study investigated the activity of the extract of Sida corymbosa on gastric ulcers induced by ethanol and the non-steroidal anti-inflammatory agent, diclofenac
Summary
There are strong beliefs in the efficacy of traditional medical systems worldwide. The increasing interest in traditional medicines in both developed and developing societies has been attributed to the economic advantage provided by traditional medicines and the accessibility and assumed safety they offer when compared to conventional medicines (Osemene et al, 2011; Kunle et al, 2012). A survey of the literature did not yield result, pointing to the lack of scientific publication on gastro-protective action or wound healing effects. This present study was designed to establish the usefulness of Sida corymbosa in the treatment of ulcers and wounds in traditional medicine. This study showed that Sida corymbosa has constituents with the ability to reduce the severity of haemorrhagic gastric lesions, promote wound healing and reduce inflammation These actions may be attributed to any one of the active constituents or as a result of synergistic effects of these phytoconstituents. Conclusion: This study validates the use of the plant in traditional medicine for the treatment of stomach ulcers and wounds
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