Abstract
28Jul 2017 ANTI-ULCER ACTIVITY OF TERMINALIA LAXIFLORA ENGL. AND DIELS LEAVES EXTRACTS AGAINST ASPIRIN INDUCED GASTRIC ULCER IN RATS. Medhat M. Menshawy , Mohamed A. El Raey , Abdel Hamid A. Hamdy and Abdel Razik H. Farrag. Department of Biology, Center of Basic Sciences, Misr University for Science and Technology, 6th October City. Departments of Phytochemistry & Plant Systematic. Chemistry of Natural & Microbial Products. Pathology, National Research Centre, Dokki, Cairo, Egypt.
Highlights
Total methanol, dichloromethane, ethyl acetate, butanol extracts from the leaves of Terminalia laxiflora were evaluated for their antiulcer activity using aspirin as ulcerogen in rats
The results showed significant reduction in the severity of ulcer and ulcer index of the treated groups as compared with aspirin group
Stomach of aspirin group showed focal necrosis of gastric mucosa associated with mucosal and submucosal eosinophilic cells infiltration
Summary
Total methanol, dichloromethane, ethyl acetate, butanol extracts from the leaves of Terminalia laxiflora were evaluated for their antiulcer activity using aspirin as ulcerogen in rats. The objective of the present study was to investigate the gastroprotective activities of Terminalia laxiflora leaves water extract and its fractions; methanol, butanol, ethyl acetate and methylene chloride by using aspirin model and to study the effect of phenolic compounds on antiulcer activity.
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