Anti-ulcer activity of Pistacia Atlantica and Punica Granatum hydroalcoholic extract in comparison with omeprazole in male wister rats

Abstract

The current study was conducted to investigate the protective effects of Pistacia Atlantica (mastic gum) hydro-alcoholic extract and Punica Granatum (pomegranate) peel hydro-alcoholic extract treatment against alcohol-induced peptic ulcer in Wister rat and to compare this protective effects between each other and with omeprazole as the most common drug in treatment of peptic ulcer. Thirty five male Wister rats were assigned into five groups (seven rats each group). C- group rats were received normal saline for one week. C+ group rats were received normal saline for one week before receiving one dose of absolute ethanol. OME group rats were received normal saline for one week and one dose of omeprazole one hour before receiving one dose of absolute ethanol. MG group rats were received Pistacia Atlantica hydro-alcoholic extract for one week before receiving one dose of absolute ethanol. PG group rats were received Punica Granatum hydro-alcoholic extract daily for one week before receiving one dose of absolute ethanol. The gross and histopathology lesion of gastric ulcer were assessed. Ulcer index results showed a significant (p<0.05) differences between C+ group and other groups, However, the ulcer index of PG group was significant (p<0.05) compared with OME group.