Anti-ulcer Activity of Mollugo nudicaulis (Molliginaceae) in Rat

Abstract

Introduction:Mollugo nudicaulis (Molluginaceae plant family) is known under the vernacular name of Aferontany. It is used as a Malagasy traditional medicine against the abdominal pain. This study was undertaken to evaluate the anti-ulcer activity of Mollugo nudicaulis in the rat. Methods: The work was carried out on in vivo samples, three tests were carried out: mucoprotector, healing and anti-secretary. The hyperhemy were caused by absolute ethanol, the lesions were observed after induction of indometacine and acid secretion was stimulated by the binding of pylor. In addition, of the phytochemical analyses of Mollugo nudicaulis was which was carried out allowed us to detect various compounds such as tannins, phenolic saponins, anthocyanes, alkaloids, compounds, terpenoids and steroids. Results: The obtained results show that the mucoprotector activity of Mollugo nudicaulis has been decreasing down to 93,36 ± 1,65 % of the surface of the hyperhemy caused by the absolute ethanol. After 7 days of treatment, Mollugo nudicaulis accelerates the cicatrization of the lesions induced by the indometacine (30 mg/kg). The reduction of the lesion in the mucous membrane of the pilot batch is of 7,51 ± 1,38 mm2 and 2,31 ± 0,90 mm2 with the amount of 600 mg/kg for Mollugo nudicaulis. Concerning the test of reduction of the gastric acidity, Mollugo nudicaulis does not have the same effect. Conclusion: The obtained results bring an evidence of the traditional use of aqueous extracts of this plant in the treatment of the gastric ulcer in Madagascar.