Abstract
Meeting abstracts OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors. Activation of OX40 by agonistic antibodies is hypothesized to promote anti-tumor immunity
Highlights
OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors
Circulating and tumor-based PD biomarkers of PRO307205 activity were evaluated in EMT6 and JC tumor models using flow cytometry and multiplex gene expression assays
PD modulation that corresponded with differential antitumor activity included sustained enhancement of CD8 T cell infiltration and expression of co-stimulatory and memory T cell markers such as CD86, ICOS, CXCR3, and IL7R in EMT6 tumors but not in JC tumors
Summary
Mahrukh Huseni*, Klara Totpal, Changchun Du, Katie Dalpozzo, Jing Zhu, Deepali Rishipathak, Erin McNamara, Bernadette Jonshtone, Priti S Hegde, Ina Rhee, Lisa Damico-Beyer, Jeong Kim. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014
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