Abstract
Meeting abstracts OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors. Activation of OX40 by agonistic antibodies is hypothesized to promote anti-tumor immunity
Highlights
OX40, a TNFRSF member, is a co-stimulatory molecule expressed on antigen experienced effector T (Teff) and regulatory T (Treg) cells, including infiltrating cells in mouse and human tumors
In vitro evaluation of Teff costimulation and Treg inhibition was conducted with MOXR0916, a humanized anti-human OX40 mAb, using purified T cells from healthy human donors
Circulating and tumor-based PD biomarkers of PRO307205 activity were evaluated in EMT6 and JC tumor models using flow cytometry and multiplex gene expression assays
Summary
Mahrukh Huseni*, Klara Totpal, Changchun Du, Katie Dalpozzo, Jing Zhu, Deepali Rishipathak, Erin McNamara, Bernadette Jonshtone, Priti S Hegde, Ina Rhee, Lisa Damico-Beyer, Jeong Kim. From Society for Immunotherapy of Cancer 29th Annual Meeting National Harbor, MD, USA. 6-9 November 2014
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