Abstract
Anti-tumor effect of phenothiazine derivatives is widely recognized. The anti-tumor effects of chlorpromazine derivatives on Yoshida sarcoma cells and Ehrlich ascites tumor were investigated. Derivatives in which Cl of chlorpromazine is replaced with Br and the carbon number of the N-side chain is elongated to 4 or 5 were more effective in anti-tumor action than chlorpromazine. Moreover, their LD50 values were much higher than that of chlorpromazine. From these results, these newly synthesized compounds might be considered for clinical trial.
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