Abstract
Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A–D ( 1– 4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C ( 3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.
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