Abstract
Sufficient knowledge regarding cellular and molecular basis of lung cancer progression and metastasis would help in the development of novel and effective strategies for the treatment of lung cancer. 4HPR is a synthetic retinoid with potential anti-tumor activity but is still limited because of its poor bioavailability. The use of albumin as a complexing agent for a hydrophobic drug is expected to improve the water solubility and consequently their bioavailability.This study investigated the antitumor activity of a novel complex between albumin and 4-HPR in a mouse model of human lung cancer and focuses on role and mechanism of Cav-1 mainly involved in regulating cancer and ACSVL3 mainly connected with tumor growth. Their expressions were assayed by immunohistochemistry and qRT-PCR, to demonstrate the reduction of the tumor growth following the drug treatment. Our results showed a high antitumor activity of 4HPR-HSA by reduction of the volume of tumor mass and the presence of a high level of apoptotic cell by TUNEL assay. The downregulation of Cav-1 and ACSVL3 suggested a reduction of tumor growth. In conclusion, we demonstrated the great potential of 4HPR-HSA in the treatment of lung cancer. More data about the mechanism of drug delivery the 4HPR-HSA are necessary.
Highlights
Lung cancer has become the most common malignant tumor and the major cause of cancer deaths worldwide
Combination chemotherapy has improved the prognosis of lung cancer, there are still many patients who have initial resistance to chemotherapy or develop it after several cycles of therapy
The identification of new therapeutic approaches is extremely important to improve the prognosis of cancer lung patients
Summary
Lung cancer has become the most common malignant tumor and the major cause of cancer deaths worldwide. Recent studies have demonstrated that Cav-1 can directly confer the anoikis resistance in NSCLC by the interaction with its antiapoptotic partner Mcl-1 protein and prevent the latter protein from the degradation by the ubiquitin-proteasomal system [17]. These results suggest that caveolin-1 plays a biological role in the regulation of tumor invasiveness, and that it should be regarded as a prognostic marker for these tumors and as a possible target for new drugs [8]
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