Anti-tumor Activity and Mechanism of Artemisinin Galactoside

Abstract

Artemisinin is a highly effective antimalarial component isolated from the Chinese medicine Artemisia annua.In addition to its antimalarial effect, artemisinin and its derivatives can also inhibit the activity of tumor cells.The glycosylation modification of artemisinin can solve the problem that it is prone to oxidation andisomerization and decompose and deteriorate. It is based on the principle that glycosyltransferase catalyzes theglycosylation reaction. This article aims to study the anti-tumor activity and mechanism of artemisiningalactosides, so this article selects derivatives with artemisinin as the mother core for structural transformation,screens them for activity, and selects a compound with high comprehensive evaluation. Its in vivo anti-tumormechanism is studied. The selected dose is 20 mg/kg, 40 mg/kg, 80 mg/kg. During the experiment, the tumordiameter was measured every other day to calculate the tumor volume (V) and relative tumor volume (RTV).The relative tumor proliferation rate T/C (%) was used as the evaluation index of the drug's anti-MDA-MB-231tumor activity in vivo. If T/C (%)> 60%, the drug was judged to be ineffective. The research data found that thetumor weight of artemisinin galactoside decreased as the dose increased, indicating that the tumor wasdose-dependent on artemisinin galactoside and inhibited tumor at the highest dose (80 mg/kg). The rate reached73.25%. Artemisinin drugs have a broad spectrum, high efficiency, and low toxicity, can selectively kill tumorcells, reverse the multi-drug resistance of tumors, and have a synergistic and synergistic effect with a variety ofchemotherapy drugs.