Abstract
BackgroundPatients with connective tissue disease, such as dermatomyositis (DM), and positive anti-TIF1γ self-antibodies are commonly diagnosed with malignant tumors as a comorbidity. The relationship between anti-TIF1γ self-antibodies and existing malignant tumors has been confirmed by several reports. However, interstitial pneumonia with autoimmune features (IPAF) cases with a positive anti-TIF1γ self-antibody developing to solid malignant tumors are rarely reported now.Case presentationHerein, we presented an IPAF patient with anti-TIF1γ self-antibodies. No evidence of malignant tumors was found at the initial visit. However, the patient had developed stage IVB lung squamous cell carcinoma at the 1-year follow-up review.ConclusionsAltogether, this report described a rare case of IPAF patient with anti-TIF1γ self-antibodies developed to advanced lung squamous cell carcinoma in 1 year. The present case highlights more frequent imaging examinations to identify the occurrence of malignant tumors as early as possible in IPAF patients with positive anti-TIF1γ self-antibodies.
Highlights
Patients with connective tissue disease, such as dermatomyositis (DM), and positive anti-Transcriptional intermediary factor 1γ (TIF1γ) selfantibodies are commonly diagnosed with malignant tumors as a comorbidity
Altogether, this report described a rare case of interstitial pneumonia with autoimmune features (IPAF) patient with anti-TIF1γ self-antibodies developed to advanced lung squamous cell carcinoma in 1 year
The present case highlights more frequent imaging examina‐ tions to identify the occurrence of malignant tumors as early as possible in IPAF patients with positive anti-TIF1γ self-antibodies
Summary
This report described a rare case of IPAF patient with anti-TIF1γ self-antibodies developed to advanced lung squamous cell carcinoma in 1 year.
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