Abstract
The salivary secretion of Rhodnius prolixus inhibits arachidonic acid-induced platelet aggregation and the accompanying rabbit aorta-contracting activity. Results are presented that show antagonism to thromboxane A 2 on both platelet aggregation and rabbit aorta preparations. The antagonist is heat stable, non degradable by pronase, non dialysable and is sensitive to periodate oxidation. A brief review of the pharmacological properties of Rhodnius saliva is presented. It is suggested that Rhodnius prolixus developed salivary anti-haemostatic components that allows them to take a large meal in a short time.
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