Abstract
Purpose: To explore the effects of Carthamus tinctorius L. (CTL) extracts on thrombosis in rats.Methods: CTL extract was obtained in hot water (60 oC), dried in a hot air oven and then freeze-dried.The rats were divided into 6 groups: normal group, control group, reference group (aspirin 5 mg/kg) as well as groups that received 20, 40 and 80 mg/kg doses of CTL, respectively. For each group, treatment was given orally once daily for 14 days. Common carotid artery FeCl3-induced thrombus and inferior vena cava thrombosis occlusion time, as well as plasma concentrations of thromboxane B2 (TXB2) and 6-keto-prostaglandine F1α(6-keto-PGF1α) were measured in rats.Results: Compared with the control group, all doses of CTL extracts significantly and dose-dependently prolonged thrombosis occlusion time, reduced the weight of thrombus and increased inhibition rate (p < 0.01). Plasma TXB2 concentration of all CTL extracts groups decreased dose-dependently (p < 0.05) while that of 6-keto-PGF1α was increased (p < 0.05). There was association between 6-keto- PGF1α/TXB2 and arterial or venous thrombus weight for all treatments, and also with occlusion time for CTL treatment but not for aspirin.Conclusion: CTL has a significant effect on thrombosis in rats. However, further studies are required to determine its clinical potentials.Keywords: Carthamus tinctorius L., Thrombosis, Thromboxane B2, 6-Keto-prostaglandin F1α, Aspirin, Occlusion time
Highlights
Carthamus tinctorius L. or safflower, commonly called Honghua in Chinese, is an annual or biennial herbal plant in the family of Compositae
Due to its traditional use of Carthamus tinctorius L. (CTL) in the prevention of cardiovascular disease [8], this study was performed on models of thrombosis in rats and compared to the standard antiplatelet agent, aspirin [9]
There was an asymptotic relationship between this 6keto-PGF1α to thromboxane B2 (TXB2) ratio and arterial or venous thrombus weight (Fig 1), and a slightly more complex relationship between the 6-keto-PGF1α to TXB2 ratio and arterial occlusion time: though the value for the highest dose of CTL was in line with control and aspirin values, the values for low and medium doses of CTL were clearly above that line (Fig 2)
Summary
Carthamus tinctorius L. or safflower, commonly called Honghua in Chinese, is an annual or biennial herbal plant in the family of Compositae. Due to its traditional use of CTL in the prevention of cardiovascular disease [8], this study was performed on models of thrombosis in rats and compared to the standard antiplatelet agent, aspirin [9]. Occlusion time, reduced the weight of thrombus and increased inhibition rate (p < 0.01).
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