Abstract
Thermal skin aging refers to skin aging induced by heat shock treatment. Apple mint (Mentha suaveolens Ehrh.) has been used as a folk medicine to treat various diseases. However, the activity of apple mint in thermal skin aging has yet to be investigated. In this study, we conducted various biological assays to demonstrate the anti-thermal skin aging activity of extracts of apple mint leaves (ALE). As a result, ALE showed significant antioxidant activities and inhibited the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and interleukin-8 (IL-8) as well as suppressed mitogen-activated proteins kinases (MAPKs) such as extracellular signal regulated kinases (ERK), c-Jun N terminal kinases (JNK), and p38 MAPK triggered by heat shock treatment in human dermal fibroblasts (HDFs). Consequently, ALE could be used as attractive cosmetic materials with anti-thermal skin aging activity.
Highlights
Skin aging is a biological process, which leads to accumulation of structural and physiological alterations, in addition to changes in skin appearance [1]
We found that apple mint leaves (ALE) was effective in preventing the formation of reactive oxygen species (ROS) stimulated by heat shock treatment (Figure 1)
We found that heat shock induced phosphorylated form of extracellular signal regulated kinases (ERK), Jun N terminal kinases (JNK), and p38 in human dermal fibroblasts (HDFs) and ALE prevented the activation of these mitogen-activated proteins kinases (MAPKs) signaling induced by heat shock treatment (Figure 3)
Summary
Skin aging is a biological process, which leads to accumulation of structural and physiological alterations, in addition to changes in skin appearance [1]. Among the various environmental factors, heat is a crucial factor causing skin aging, which is called thermal skin aging [3]. Human skin is usually exposed to considerable amounts of infrared (IR) radiation from sunlight [5]. This IR radiation causes the generation of heat through molecular vibrations and rotations, which increases the skin temperature and has an influence in skin aging [6]. Human skin is frequently exposed to heat formed by using electronic devices such as smart phone, hair dryer, stove, and similar devices, which increase skin temperature and induce skin aging as well [3]
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