Anti-Skin-Aging Effect of a Treatment with a Cosmetic Product and a Food Supplement Based on a New Hyaluronan: A Randomized Clinical Study in Healthy Women

Abstract

Hyaluronic acid (HA) has long been used for its anti-age properties, as an ingredient in both topical applications and food supplements. In this study, a novel sodium hyaluronate, based on the innovative full spectrum technology, was administered as an ingredient of a cosmetic product and as the main constituent of a food supplement to evaluate its efficacy in counteracting skin ageing signs. Seventy-five female subjects were randomly assigned to the following treatments for 4 weeks: an active food supplement and a placebo cosmetic product, an active cosmetic product and a placebo food supplement, and a combination of the two products containing the active ingredient, that is, an “In&Out” treatment. The subjects used the placebo cosmetic product for another 14 days. Improvement of all the outcome measures (skin moisturization, elasticity, firmness and profilometry) was achieved by all treatments (p < 0.05); however, the combined treatment resulted in a further amelioration of the skin aging signs with respect to the two single active treatments (p < 0.001), and such effect lasted also after the follow-up period. In conclusion, such results confirmed that the concomitant administration of hyaluronans by these two different routes represents more than an interesting approach to counteract skin aging signs.