Anti-recurrent Immunocorrection in Gynecology Andrology and Proctology

Vasyl Beniuk,Sergii Melnikov,Vadym Goncharenko,Svitlana Vintoniuk,Sergii Podpriatov,Kamil Nurimanov,Oleksii Tatskyy,Andrii Kurchenko,Sergii Konovalenko

doi:10.11648/j.iji.20200801.11

Abstract

The article provides evidence of clinical experience with the use of Arecur® for the treatment of endocervicitis and dysplasia of the cervix, endometrioma, chronic bacterial prostatitis, and for postoperative rehabilitation in patients after removal of hemorrhoids. Arecur® contains exogenous peptides of natural origin – anti-infective proteins of the group of defensins and RJP-1 and has antibacterial, antiviral, anti-inflammatory and antitumor activity. In the study groups, in which Arecur® was assigned to the patients, were reported significantly better clinical efficacy results. The ability of exogenous peptides to mobilize T-lymphocytes to identify and destroy infected and atypical cells determines the elimination of human papilloma virus and creates the conditions for reducing the risk of malignant cell transformation of cervical canal. Arecur®, by enhancing the immune supervision of ectopic endometrial cells, promotes regression of clinical symptoms and prolongation of inter-relapsing intervals in patients with endometriosis. In chronic bacterial prostatitis Arecur® increases the efficiency of etiotropic and symptomatic therapy. After surgical removal of hemorrhoid lesions, Arecur® provides more positive dynamics of rehabilitation, improves patients' quality of life and prevents complications. The obtained results allow us to reasonably recommend Arecur® as a medicine for anti-recurrent immunocorrection in gynecology, andrology and proctology.

Highlights

Peptides, as the primordial matrix of life management, appeared on our planet more than three billion years ago and are integral links of biochemical reactions that provide an adequate response to damage in organism
The synthesis of TNF-α by immunocompetent cells and, as a consequence, the recruitment of inactive Tlymphocytes in the microenvironment of the endometrioma naturally leads to the initiation of programmed death of ectopic cells, where the caspase system plays the leading role in the cascade
The relative risk of detecting clinical manifestations 6 months after the end of therapy in the main group was reduced by 65.6% - OR = 0.344 (0.12-0.96), p = 0.022. These results speak in favor of the inclusion of exogenous peptides in the complex treatment of endometriosis, and in favor of the modern concept that the ectopic endometrial cell, being essentially a normal cell but in an atypical location, finding itself in a new place, acquires new signs that may contribute to its transformation into a target for active immunocompetent cells [13,14,15]

Summary

Introduction

As the primordial matrix of life management, appeared on our planet more than three billion years ago and are integral links of biochemical reactions that provide an adequate response to damage in organism. It was found that peptides have the most ancient, formed evolutionary properties: protection of cells from harmful factors and an adequate response of immune system to a possible danger. [1, 2] Years of researches have shown, that peptides activate immune cells, set up lymphocytes on destruction of pathogenic bacteria and viruses, stimulate antitumor immunity. The interaction is not selective: peptides (A) make contact with all cells (B), irritating their receptors, altering the physicochemical and electrical characteristics of the membranes. The target cells are re-tested with T-lymphocytes (C), thereby increasing the likelihood of detecting an atypical cell (D) and killing and recycling it with macrophages (E). (Figure 1) [5]

Methods

Results

Conclusion