Abstract
Aim: To evaluate the effect of an active fraction from Cassia occidentalis leaves on Wistar rats against psychosis were investigated.
 Place and Duration of Study: This study was carried out in the Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore, India between June -2019 to July – 2020.
 Methods: For the assessment of neuroleptic activity of the Cassia occidentalis leaves with different antipsychotic animal models, Chloroform and ethanol extract (200 mg.kg-1) were used for the study with different animal models. The extract showing higher anti psychotic activity was subjected to column chromatography and led to the isolation of an active fraction and examined in GC-MS analysis.
 Results: A significant decrease of amphetamine-caused stereotype and conditioned avoidance reaction turned into found with extract treated animals as in comparison to control. Phencyclidine induced weird sample of locomotor activity and social withdrawal test in test extracts does no longer proven any significant activity as in comparison to control. Minor symptoms of catalepsy have been seen extract-treated group and decreased dopamine level in the frontal cortex and corpus striatum in comparison to the control group. GC-MS evaluation was identified two active principles present in the eluted fraction.
 Conclusion: The study revealed that the ethanol extract of Cassia occidentalis may possess the property to alleviate the positive symptoms of psychosis.
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