Abstract
This study focuses on the anti-protozoan activities of Stachytarpheta angustifolia (Tarkajiya; Hausa, Devil’s coach whip; English) on haematological parameters of Albino Wistar rats which is an unexplored study area. The work is aimed at the determination of the effects of S. angustifolia on Wistar Rats, when exposed to herbal extract on the haematological parameters of Wistar Rats infected with E. tenella Biomarkers. The plant was obtained whole; dried under the shade, made into a powdered form and aqueous extraction method carried by maceration technique. After infecting the experimental animals with the parasites; E. tenella, the following respective doses of 750 mg and 1500 mg were administered to the rats in groups of 3 and 4. Results obtained were analyzed using Analysis of Variance (ANOVA). It was discovered that no significant harmful effect on the rats was recorded, but 60 % of the parasites were killed. This work demonstrated that the herbal extract killed the parasites but induced minimal stress to the animals as shown by the low haematological parameters in the study.
Highlights
Research on herbal medicine has been in existence since time immemorial and it is still ongoing
The aim of this study is to investigate the antiprotozoan activities of Stachytarpheta angustifolia on some haematological parameters in albino wistar rats
Reaction of Rats after induction with crude herbal extracts (LD50) Table 3 shows the relative doses of the extract administered to the three groups of rats in this experimental LD50 group, the extracts were administered in ascending doses from 750 mg for all the members of first group of rats, 1000 mg of the extract was served to group two rats, while, 1500 mg was given to the rats in group three
Summary
Research on herbal medicine has been in existence since time immemorial and it is still ongoing. Its (medicinal plants) use is increasingly relied on in the industrialized societies, which has been traced to the extraction and development of several drugs and chemotherapeutics from these plants as well as from traditionally used rural herbal remedies. Plants have been used as medicine for millennia, and out of estimated 250,000 to 350,000 plant species identified so far, about 35,000 are used worldwide for medicinal purposes It has been confirmed by WHO [3], that herbal remedies serve the health needs of about 80 percent of the world’s population; especially for millions of people in the vast rural areas of under-developed countries. The recent resurgence of plant remedies results from several factors like: the effectiveness of plant medicines, the side effect of most modern drugs, and the development of science and technology.
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