Anti-proliferative Effect of Nine Resins from Medicinal Plants of Burkina Faso

Abstract

Exudates are substances that ooze out of the pores of diseased and/or damaged tissue in plant that are well-used in flourishing international and local uses in Burkina Faso. Previously, the ethnopharmacological investigations in Center region showed that there are lot of medicinal uses like as old wounds, skin disorders diseases treatment. The current study aims to highlight the antitumoral potential of nine resins form central region. One hundred grams of each resin were placed at -80°C before extraction. The resins were grinded, and the powder was stirred twice with 1L and 500 mL of CHCl₃ respectively for 24h. The antiproliferative effect was determined by using MTT colorimetric assay with chloroformic extracts from resin of each plant and the concentrations which inhibited 50% of cell proliferation (IC₅₀) were determinated graphically. The results showed that the IC₅₀ of A549 proliferative inhibition was form 5.78 (<i>Lannea microcarpa</i>) to 32.48 µg/mL (<i>Daniellia oliveri</i>) and U373 inhibition IC₅₀ was from 12.90 (<i>L. macrocarpa</i>) to 41.12 µg/mL (<i>Boswellia dalzielli</i>). The Keratinocytes IC₅₀ was form 1.57 (<i>L. macrocarpa</i>) to 20.4 µg/mL (<i>Boswellia dalzielli</i>). Interestingly, the resin extract form <i>L. macrocarpa</i> resin was a best source of anticancer compounds for the A549 and U373 following by <i>Bombax costatum</i> resin. In the contrast <i>Commiphora africana</i> (Burseraceae) resin was the less antiproliferation effect. The exudates resin from plants that were a source of bioactive compounds could explain of the medicinal uses like as anti-inflammatory, wound healing, and skin ailments in Burkina Faso.