Abstract
In the present study, the chemical investigation of the bioactive fractions of the rhizomes of Zingiber officinale has resulted in the identification of twenty-nine compounds including one new compound, O-methyldehydrogingerol (1). Some of the isolates were subjected into the evaluation of their antiplatelet aggregation and vasorelaxing bioactivities. Among the tested compounds, [6]-gingerol (13) and [6]-shogaol (17) exhibited potent anti-platelet aggregation bioactivity. In addition, [10]-gingerol (15) inhibited the Ca2+-dependent contractions in high K+ medium. According to the results in the present research, the bioactivity of ginger could be related to the anti-platelet aggregation and vasorelaxing mechanism.
Highlights
Ginger is the rhizome of Zingiber officinale, a perennial plant in the family Zingiberaceae
The most famous traditional medicinal practice of Z. officinale is to promote the blood circulation for removing blood stasis and the mechanism is related to anti-platelet aggregation activity [2]
According to the purified constituents and bioactivity in the present research, the function of ginger to promote the blood circulation for removing blood stasis could be related to anti-platelet aggregation and vasorelaxing mechanism
Summary
Ginger is the rhizome of Zingiber officinale, a perennial plant in the family Zingiberaceae It is consumed as delicacy, medicine, or spice. In the course of our continuing research program aimed to discover novel bioactive constituents from natural sources, screening work for thrombolytic and vasoactive activity was carried out and the ether extract of the rhizome of Z. officinale was found to show anti-platelet aggregation activity and produce a vasorelaxing effect. This initiated our interest in studying the bioactive principles in the rhizome of. We report the characterization of twenty-nine compounds and the bioactivity of some of these purified compounds
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