Abstract
Anti-synthetase syndrome (ASS) is a rare systemic autoimmune disease characterized by a combination of ILD , myopathy, fever and polyarthralgia and Raynaud's phenomenon and mechanic's hand . Hallmark of ASS is the presence of antibodies against aminoacyl tRNA synthetase enzyme. The most commonly encountered autoantibody is anti-JO 1 (around 80%), less commonly encountered are anti pl 7, anti-PL 12 anti E J. (1) Here we report the case of a 45 year old lady presenting with features of ASS where anti PL 12 was positive but with a negative anti JO 1.
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