Abstract
Sinapic acid is a phenylpropanoid compound extensively found in spices, citrus and berry fruits, vegetables, cereals, and oilseed crops. Sinapic acid is known to exhibit antioxidant, anti‐inflammatory, anticancer, antimutagenic, antiglycemic, neuroprotective, and antibacterial activities. However, the inhibitory effect of sinapic acid on photoaging has not been fully investigated. The aim of this study was to investigate the protective effect of sinapic acid on UVB‐induced photoaging through PPARδ mediated mechanism in Hs68 cells. Sinapic acid attenuated UVB‐induced expression of MMP‐1 and increased the production of collagen in Hs68 cells. Furthermore, UVB‐induced ROS generation was markedly attenuated by pretreatment with sinapic acid, demonstrating that sinapic acid is to be a potent ROS scavenger. These effects were abolished by treatment with GSK0660, a specific inhibitor of PPARδ. These results suggest that PPARδ is a key regulator of UVB‐induced photoaging and sinapic acid may ameliorate the UVB‐induced photoaging in human skin fibroblasts through modulatiing PPARδ expression.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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