Abstract
A systemic administration of aqueous form of peptidoglycan polysaccharide polymer (PG-APS) derived from S. pyogenes induced acute and chronic form of polyarthritis in all the rat strains tested. SHR developed severe arthritis 24 hours after injection and developed very low titer of IgM and IgG antibody to PG-APS whereas WKY appeared to be resistant to polyarthritis but developed high titer of antibody to PG-APS. Congenitally athymic nude rats developed acute polyarthritis and high titer of antibody but developed chronic form of polyarthritis only after multiple injection of PG-APS whereas euthymic rnu/+ rats easily developed severe acute and chronic polyarthritis and developed relatively lower titer of antibody than rnu/rnu rats. There existed good correlation between antibody formation and acute polyarthritis among rnu/rnu and rnu/+ rats whereas no correlation existed between chronic form of polyarthritis and antibody formation.Acute exacerbation of polyarthritis occured within 24 hours after booster injection of PG-APS but no secondary antibody response were observed. It was thus considered that the pathogenesis of this polyarthritis may be different from that of adjuvantinduced arthritis where T cell may play an important role and whether or not antibody to PG-APS is associated with the development of polyarthritis.
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