Abstract
High molecular weight chitosan (HMWC) was degraded to prepare chitosan with different molecular weight based on the fenton reaction, which can produce aggressive OH-radicals produced from hydrogen peroxide in the presence of catalytic metal ions. The relative molecular weight, anti-oxidant activity, and fine dust removal effect of chitosan hydrolysates were elucidated to define their molecular weight and their potent biological activity. Our results demonstrate that chitosan hydrolysates derived from the hydrolysis of HMWC may possess significant free-radical scavenging activity as good anti-oxidants against the radical scavenging activity of DPPH and ABTS, respectively. Furthermore, chitosan hydrolysates can effectively eliminate fine dust, which may contain some particulate matter (PM) and unknown species of microorganisms from the air, suggesting that our data provide important information for producing air filters, dust-proof masks and skin cleaner for the purpose of human healthcare and well-being.
Highlights
Chitosan with different molecular weight was firstly considered as a potent factor for determining various biological activities such as anti-oxidant [1,2], anti-bacterial [3,4], anti-cancer [5,6], anti-fungal [7,8], etc
Upon investigating the significance of the fenton reaction for the degradation of several biomaterials, we currently tried to make chitosan with different molecular weights derived through the hydrolysis of high molecular weight chitosan (HMWC, ~600 kDa, 98.5% deacetylation degree, α-form) under optimal conditions
Chitosan hydrolysates with different molecular weights were prepared in a rapid reaction, referred to as fenton oxidative cleavage, in the presence of catalytic metals
Summary
Chitosan with different molecular weight was firstly considered as a potent factor for determining various biological activities such as anti-oxidant [1,2], anti-bacterial [3,4], anti-cancer [5,6], anti-fungal [7,8], etc. Less is known about how these molecules can be prepared effectively and economically for use as potent bioactive materials. Like polysaccharides, can be degraded under oxidative reaction produced by reactive oxygen species (ROS) [9,10], we have tried to prepare chitosan hydrolysates with different molecular weights under these conditions. OH-radicals have been identified as specific species of ROS that are capable of degrading some polysaccharides isolated from natural resources [11,12]
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