Abstract
The oedema disk technique was used to study the effects of intraperitoneally administered H1-receptor antagonists (chloropyramine, cyproheptadine and dimethindene maleate) on the inflammation induced with dithranol in the mouse ear. In rats of the Wistar strain, oedema was induced in the hind paw by the subplantar injection of carrageenin, and simultaneously by the application of croton oil to the inner surface of the ear. Preliminary antihistamine treatment inhibited the development of oedema in the mouse ear, and of both types of oedema in rats, to statistically significant extents and in a dose-dependent manner.
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