Year-end Sale % OFF 
Abstract
Obesity is a multifactorial metabolic disorder characterized by low-grade chronic inflammation, hyper-permeability of the gut epithelium, and perturbation of the intestinal microbiome. Despite the numerous therapeutic efficacies of Dictyophora indusiata mushroom, its biological activity in alleviating obesity through regulation of the gut microbiota and inflammatory cascades remain obscure. Henceforth, we determined the modulatory impact of D. indusiata polysaccharide (DIP) in the high-fat diet (HFD)-induced obesity mice model. The experimental subjects (BALB/C mice) were supplemented with chow diet (Control group), high-fat diet (HFD group), or HFD along with DIP at a low dose [HFD + DIP(L)] and high dose [HFD + DIP(H)]. Obesity-related parameters, including body weight gain, epididymal adipocyte size, fat accumulation, adipogenic markers, lipogenic markers, inflammatory associated markers, intestinal integrity, and intestinal microbiome, were elucidated. Our findings demonstrated that the oral administration of DIP at low dose partially and at high dose significantly reversed HFD-induced obesity parameters. Furthermore, the body weight, fat accumulation, adipocyte size, adipogenic and liver associated markers, glucose levels, inflammatory cytokines, and endotoxin (Lipopolysaccharide, LPS) levels were reduced considerably. Moreover, the study revealed that DIP treatment reversed the dynamic alterations of the gut microbiome community by decreasing the Firmicutes to Bacteroidetes ratio. These findings led us to infer the therapeutic potential of DIP in alleviating HFD-induced obesity via regulating inflammatory cascades, modulating intestinal integrity and intestinal microbiome community.
Highlights
Obesity is one of the major health concerns across the world that has been implicated with multiple health problems and a reduced life expectancy [1, 2]
high-fat diet (HFD) feeding for 8 weeks led to a significant increment of the body weight, liver weight, epididymal, and subcutaneous fat accumulation compared with the control group (Figures 2A–F)
Our findings revealed a significant reduction of body weight, liver weight, epididymal, and subcutaneous fat accumulation in D. indusiata polysaccharide (DIP) intervention groups in a dose-dependent manner as compared to the HFD alone group (Figures 2A–F)
Summary
Obesity is one of the major health concerns across the world that has been implicated with multiple health problems and a reduced life expectancy [1, 2]. 500 million individuals are obese, and 1.4 billion are overweight globally [4]. Obesity is characterized by excessive fat accumulation due to various factors, including genetic predisposition, high-calorie energy intake, and sedentary lifestyle [5]. Obesity predisposes an individual to develop and aggravate a broad spectrum of disorders, including type 2 diabetes, insulin resistance, fatty liver disease, gastrointestinal problems, cardiovascular disease, respiratory problems, and various kinds of cancers [6,7,8,9]. Considering the adverse impact of obesity on individual health, it is of great challenge to reduce and halt obesity in the modern world
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
