Anti-obesity and hypolipidemic effect of water extract from Pleurotus citrinopileatus in C57BL/6J mice.

Yao Sheng,Xiaoyun He,Shujuan Zheng,Changhui Zhao,Kunlun Huang,Xiaohong Mei,Guoyi Wang

doi:10.1002/fsn3.962

Abstract

Obesity has become one of the most important health problems worldwide requiring urgent need for efficient control. Pleurotus citrinopileatus (P. citrinopileatus)—a type of edible mushroom with abundant bioactive molecules—is a promising source for achieving this goal. In the present study, we evaluated the anti‐obesity and hypolipidemic effect of P. citrinopileatus water extract (PWE) using a series of biochemical assays in randomized high‐fat diet‐induced obese (DIO) C57BL/6J mice, which were gavaged daily with low or high levels of PWE (400 or 800 mg/kg of body weight, respectively) in addition to high‐fat diet for 12 weeks. Results showed that PWE significantly reduced the weight gain, fat accumulation, and food intake of DIO mice within 12 weeks. PWE also decreased the serum triglycerides, cholesterol and low‐density lipoprotein, aspartate transaminase, nonesterified fatty acid, and creatinine, but increased high‐density lipoprotein. Additionally, PWE improved the glucose tolerance of mice fed with high fat. From above, we conclude that PWE has great potential as functional foods for management of obesity and/or associated metabolic disorders.

Highlights

Obesity is one of the most important health problems worldwide, especially in developed countries (Novick, 2016; Talmor & Dunphy, 2015)
Obesity is associated with higher risk of many diseases such as type 2 diabetes, hyperlipidemia, and cardiovascular disease (Sullivan, FIGURE 2 Effect of P. citrinopileatus water extract (PWE) on blood lipid profile, enzymatic activity, and clinical biochemistry in mice. (a) PWE slightly decreased the nonesterified fatty acids in mice fed with a high‐fat diet, but this difference failed to reach a significant level. (b) There was no significant difference in the levels of several enzymes (ALT, AST, alkaline phosphatase (ALP), and lactic dehydrogenase (LDH)) between the diet‐induced obese (DIO) mice and the VC mice
PWE improved the condition of the DIO mice in glucose intolerance, which is a prediabetic state of hyperglycemia that is closely associated with obesity or metabolic syndrome (Huang, Chiang, Yao, & Chiang, 2010; Zhao & Castonguay, 2017)

Summary

| BACKGROUND

Obesity is one of the most important health problems worldwide, especially in developed countries (Novick, 2016; Talmor & Dunphy, 2015). Accumulating evidence shows that water extracts from P. citrinopileatus have many beneficial functions including antitumor activity (Zhang et al, 1994), immune‐enhancing. The PWE has high content of water‐soluble polysaccharides as well as phenol compounds (12.38 mg/g) (He et al, 2016; Lee et al, 2007). Water‐soluble polysaccharides from mushrooms were frequently shown to be beneficial in health maintenance (Xu et al, 2010; Yashvant, Naraian, & Singh, 2012). A recent report showed that polysaccharides extracted from Ganoderma lucidum—another type of well‐known edible fungi—effectively reduced body weight in mice by modulating the composition of the gut microbiota (Chang et al, 2017). We were attempting to investigate the anti‐obesity and hypolipidemic functions of the water extract from P. citrinopileatus (PWE) in high‐fat diet‐induced obese (DIO) mice

| METHODS

Findings

| DISCUSSION

| CONCLUSIONS