Abstract
Raphani Semen (RS) has been used to treat digestive disorders in Korean oriental medicine. The hypolipemic and anti-obese effects of the aqueous extracts of RS in mice provided with high fat diet (HFD) were evaluated. HFD caused increased T-Chol, triglyceride, and LDL, and decreased HDL levels. Mice fed HFD exhibited signs of obesity including increased body weight, fat weight, and serum leptin level, and decreased serum adiponectin level. Histopathological analysis revealed that the mean diameter of adipocytes was increased by HFD supply. However, these increases in the hyperlipemia and obesity indices were attenuated by RS treatment in a dose-dependent manner, and similar effects were detected in mice treated with equal dosages (250 mg/kg) of metformin and RS. These results indicate that the aqueous extracts of RS warrant further development as a protective agent for the treatment of diet-induced metabolic syndrome.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Korean Society for Applied Biological Chemistry
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
