Abstract
Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.
Highlights
Irritable Bowel Syndrome (IBS), a gastrointestinal (GI) pathology, frequently associated with psychological distress with a worldwide prevalence of 5–20%, to the diagnosis criteria, is defined by altered bowel habits, chronic abdominal pain, absence of detectable structural colon abnormalities and increased gut permeability[1]
To determine if microbiota relative abundance of F. prausnitzii-like specie could be impacted by a Neonatal Maternal Separation (NMS) stress, we further mined our Next generation sequencing (NGS) data to examine if operational taxonomic unit (OTU) of F. prausnitzii-like 16 S sequence (99% match) could be observed
NGS of the mouse fecal microbiota revealed that F. prausnitzii OTU was detected in few amount of 3 week-old control mice (33%), since it was more frequently observed in 12 week-old control mice (83%), to represent 0.003% of fecal microbiota
Summary
Irritable Bowel Syndrome (IBS), a gastrointestinal (GI) pathology, frequently associated with psychological distress with a worldwide prevalence of 5–20%, to the diagnosis criteria, is defined by altered bowel habits, chronic abdominal pain, absence of detectable structural colon abnormalities and increased gut permeability[1]. Colonic hypersensitivity (CHS) is considered as a major factor playing a role in IBS physiopathology and is clinically revealed by increased perception of colorectal distension[2]. This common complaint is a crucial feature because of its significant impact on IBS patients’ quality of life and lack of efficient therapies. Abnormalities in colonic microbiota have been suspected in IBS patients with bloating, and altered intestinal motility or sensitivity[4,5]. Growing evidence suggest that at least subgroups of IBS patients have an altered gut microbiota composition or dysbiosis[6,7]. Hypersensitive animals treated with F. prausnitzii but not with its culture SN showed a decreased colonic sensitivity in response to a colorectal distension (CRD)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
