Abstract
The present study aimed at the isolation and in vitro anti-MRSA and antioxidant properties of endophytic fungi derived from the stem of Tradescantia pallida. The fungal endophytes were isolated in a PDA agar medium. A total of seven isolates were recovered. Sequential solvent extraction was done using different polarity solvents and the crude extracts obtained were tested for their antagonistic activity against drug-resistant bacteria. In vitro, the antioxidant activity of the potent fungus was carried out by DPPH assay. Crude extract from TPS2 isolate displayed maximum inhibition towards Methicillin-resistant Staphylococcus aureus ATCC 43300 and 700699. It also exhibited free radical scavenging activity in the range of 30 to - 85%. The potential isolate was identified as Aspergillus niger. Thus, we conclude that the dichloromethane crude extract of A.niger fungal can produce antibacterial and antioxidant compounds. Hence the bioactive metabolites can be probed as antibacterial agents in treating infectious diseases.
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