Anti-Mullerian hormone in systemic lupus erythematosus

Z S Alekberova,R G Goloeva,O N Egorova,M V Cherkasova

doi:10.14412/1996-7012-2021-1-105-110

Abstract

Currently, in patients with systemic lupus erythematosus (SLE) increasing attention is paid to the ovarian reserve evaluation, which can serve as one of the markers of a favorable response to therapy and pregnancy planning. For this purpose, anti-Mullerian hormone (AMH) is considered as the most sensitive marker, that reflect the continuous growth of small follicles. The article presents data on the relationship of serum hormone levels with age, ethnicity, body weight, disease activity, and therapy. We present clinical cases of three women of childbearing age with SLE, different duration of the disease and cumulative dose of disease-modifying antirheumatic drugs in whom the level of AMH in the blood serum was measured.

Highlights

In patients with systemic lupus erythematosus (SLE) increasing attention is paid to the ovarian reserve evaluation, which can serve as one of the markers of a favorable response to therapy and pregnancy planning
Anti-Mullerian hormone (AMH) is considered as the most sensitive marker, that reflect the continuous growth of small follicles
We present clinical cases of three women of childbearing age with SLE, different duration of the disease and cumulative dose of disease-modifying antirheumatic drugs in whom the level of anti-Mullerian hormone (AMH) in the blood serum was measured

Summary

Introduction

In patients with systemic lupus erythematosus (SLE) increasing attention is paid to the ovarian reserve evaluation, which can serve as one of the markers of a favorable response to therapy and pregnancy planning. К настоящему времени проведено несколько работ, в которых сывороточный уровень AMГ использовался для оценки резерва яичников у пациенток с СКВ. Насоновой подтвержден диагноз СКВ, подострого течения, активность 3-й степени: нефрит с выраженным мочевым синдромом (суточная протеинурия 2,3 г/сут), дискоидные очаги, энантема твердого нёба, лейкопения и иммунологические нарушения (анти-ds-ДНК, комплементемия С3/С4, анти-Sm, SS-A/Rо), АНФ-Нер2 положительный.

Results

Conclusion