Anti-mullerian Hormone and Vitamin D as a predictor of Ovarian reserve and Ovarian response in Infertile women undergoing IVF

Abstract

Aim: This study was aimed to measure AMH and 25(OH)D as a predictor of ovarian reserve among infertile females undergoing IVF in Iraq. Objective: To estimate anti-mullerian hormone as a predictor of fertility potential in terms of ovarian reserve and ovarian response reflected by antral follicles and mature oocyte counts in response to stimulation in in vitro fertilization (IVF) females. Materials and Methods: This prospective cohort study consisted of 60 women (mean age 26.67 years) undergoing IVF at Al-Amal Fertility Center in Baghdad. Blood withdrawal for Anti-mullerian hormone, vitamin D, FSH and E2 measurement was performed in all the patients and the number of oocytes were recorded. Results: Results showed that the ovarian response was better with younger age ( 16 There was a significant positive association between ovarian response in terms of total number of oocytes and AMH levels ( 16 oocytes there was no association between ovarian response in terms of total number of oocytes and vitamin D, FSH and E2 Moreover, Correlation coefficient revealed that the number of mature oocytes showed strong positive correlation with the AMH levels (r=5.27, p=0.001). The total number of oocytes was inversely associated with age There was a significant positive association between ovarian response in terms of the total number of oocytes and AMH levels there was no association between ovarian response in terms of the total number of oocytes with 25(OH)D FSH and E2 implying that AMH can be used as a good predictor of ovarian reserve and ovarian response. Conclusion: Anti-mullerian hormone can be used in IVF programs as a good predictor of ovarian reserve and ovarian response.