Anti-microbial glycosides of Euptelea polyandra Sieb. et Zucc. I. Isolation, constitutions and anti-microbial activities of eupteleside A and eupteleoside B

Abstract

Two new glycosides, named eupteleoside A (I) and eupteleoside B (II), were isolated from the leaves of Euptelea polyandra SIEB. et ZUCC. (Eupteleaceae). I, C46H70O17·2H2O, was shown to be a triterpene saponin which gave upon acid hydrolysis the aglycone eupteleogenin and one mole each of L-rhamnose, L-arabinose, and D-glucose. II, C48H72O18·H2O, was correlated to I establishing that II is a monoacetate of I. I and II showed relatively intense anti-microbial activity against Saccharomyces cerevisiae and Piricularia oryzae, as well as some phytopathogenic fungi. Synergistic effect of I and II is also described.