Abstract
Problem statement: To evaluate the effects and mechanisms of action involved in anti-ulcer, antioxidant and antimicrobial activities of different native shilajit samples. Approach: Shilajit samples were collected in the mountain region of Yemen (Al-Jouf and Rayma), Russia (Tien-Shan) and India (Kumoan). Stomach ulcers were induced in rats by oro-gastric ingestion of ethanol/HCl. Pre-treatment with ranitidine (100 mg kg-1, p.o.) and shilajit samples (600 mg kg-1, p.o.) occurred for 14 days before the ulcer induction. Plasma lipids, TBARs, SOD, GSH, catalase activity and gastric mucosal histological changes in rat stomach tissue were evaluated. Antimicrobial efficacy of shilajit (500, 300 and 100 μg disc-1) was also studied against fungi, gram positive and negative bacteria. Results: Data had shown the hypo-lipidemic and anti-oxidant effects of studied shilajit samples on ethanol/HCl-induced ulcer model via decreasing TGs, Tc, TBARs while increasing HDLc, SOD, catalase and GSH than saline or ranitidine pre-treated groups. Al-Jouf and Indian shilajit samples inhibit both ulcer score and lesion area by greater percentages than either ranitidine or other samples. Rayma and Russian samples showed a strongest antimicrobial effect than either Al-Jouf or Indian samples. Conclusion/Recommendations: Some of studied shilajit samples have anti-oxidant and anti-ulcer against induced gastric ulcer, while others showed anti-microbial activities against tested microbes; mightily due to combined mechanisms of shilajit’s constituents, including hypolipidemic, antioxidant, anti-inflammatory, anti-stress, anti-anxiety, regenerative, repairing and healing mechanisms.
Highlights
Yemen, Asian parts of Russia and neighboring areas (Ghosal et al, 1991; Agarwal et al, 2007)
Shilajit is a herbo-mineral, marine animal origin- samples from different regions of the world have dead/fossil invertebrates, semi-hard brownish black similar physical properties and qualitative chemical resin formed through long-term humification of several plant types, mainly bryophytes such as Euphorbia and Trifolium plants and lichen, present in the vicinity of shilajit-exuding rocks
It is found in specific mountain regions of the world at altitudes between 0.6 and 5 km on the walls of caves, embedded in rocks or as rock exudates and can exceed 500 kg in weight; in Kashmir, Afghanistan, Nepal, Bhutan, Pakistan, China, Tibet, composition but they differ in the ratio of individual components (Galimov et al, 1986)
Summary
Asian parts of Russia and neighboring areas (Ghosal et al, 1991; Agarwal et al, 2007). Its. Shilajit is a herbo-mineral, marine animal origin- samples from different regions of the world have dead/fossil invertebrates, semi-hard brownish black similar physical properties and qualitative chemical resin formed through long-term humification of several plant types, mainly bryophytes such as Euphorbia and Trifolium (clover) plants and lichen, present in the vicinity of shilajit-exuding rocks. Shilajit is a herbo-mineral, marine animal origin- samples from different regions of the world have dead/fossil invertebrates, semi-hard brownish black similar physical properties and qualitative chemical resin formed through long-term humification of several plant types, mainly bryophytes such as Euphorbia and Trifolium (clover) plants and lichen, present in the vicinity of shilajit-exuding rocks This plant type of shilajit called Mumie-asil to being distinguished from other types (petroleum mumie and mumiekiem). The present study aimed to compare among shilajit samples of different native origin {Yemen (Al-Jouf and Rayma), Russia (Tien-Shan) and India (Kumoan)} in: antimicrobial antioxidant and gastro-protective activity against ethanol/HCl induced gastric ulcer in rat
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
