Anti-Melanoma Capability of Contactless Cold Atmospheric Plasma Treatment.

Dayun Yan,Michael Keidar,Alisa Malyavko,Qihui Wang,Xiaoliang Yao

doi:10.3390/ijms222111728

Dayun Yan, Michael Keidar + Show 3 more

Open Access

https://doi.org/10.3390/ijms222111728

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Abstract

In this study, we demonstrated that the widely used cold atmospheric plasma (CAP) jet could significantly inhibit the growth of melanoma cells using a contactless treatment method, The flow rate of helium gas was a key operational parameter to modulate electromagnetic (EM) effect on melanoma cells. Metal sheets with different sizes could be used as a strategy to control the strength of EM effect. More attractive, the EM effect from CAP could penetrate glass/polystyrene barriers as thick as 7 mm. All these discoveries presented the profound non-invasive nature of a physically based CAP treatment, which provided a solid foundation for CAP-based cutaneous/subcutaneous tumor therapy.

Highlights

Cancer is a significant threat to human health [1]
The search for topical, local, and non-invasive treatments for managing cancers is a mainstay in modern medicine, especially for superficial tumors such as melanoma or squamous cell carcinoma [2]
We proposed the following strategies to perform physically based treatment by blocking chemical factors, which natstrategies to perform physically based treatment by blocking chemical factors, which urally realized a contactless treatment between andand cancer cells

Summary

Introduction

Cancer is a significant threat to human health [1]. The search for topical, local, and non-invasive treatments for managing cancers is a mainstay in modern medicine, especially for superficial tumors such as melanoma or squamous cell carcinoma [2]. Due to the cutaneous or mucosal nature of melanoma, it may be one of the most promising candidates for CAP-based cancer therapy [3]. Even for melanoma, the tumorous tissue will not directly expose to plasma without the help of surgery, not to mention other deep tumors. There is an urgent need to explore the non-invasive potential of CAP treatment, contactless treatment based on physical factors. As a non-equilibrium plasma, CAP acts through both chemical and physical factors [4]

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